The village of Porto di Mezzo developed along the river during the 13th century as a river port and the port of departure for a ferry that connected the two banks of the Arno River.
Because it was located on a small island, at a point where the river divided into two branches, it was named “Mezzana a Signa”.
Before the villages of San Martino a Gangalandi and Lastra a Gangalandi were joined to become the municipality of Lastra a Signa, it was a dependent of the municipality of San Martino.
In medieval times, the village became the “Port of Florence”, the main commercial river port in the Florentine possessions, useful for connections with the outlet to the sea at Livorno.